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KMID : 0352720140380040239
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Journal of Ginseng Research
2014 Volume.38 No. 4 p.239 ~ p.243
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An 8-wk, randomized, double-blind, placebo-controlled clinical trial for the antidiabetic effects of hydrolyzed ginseng extract
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Park Soo-Hyun
Oh Mi-ra
Choi Eun-Kyung
Kim Min-Gul
Ha Ki-Chan
Lee Seung-Kwon
Kim Young-Gon
Park Byung-Hyun
Kim Dal-Sik
Chae Soo-Wan
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Abstract
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Background: To investigate the antidiabetic effects of hydrolyzed ginseng extract (HGE) for Korean participants in an 8-wk, randomized, double-blinded, placebo-controlled clinical trial. Methods: Impaired fasting glucose participants [fasting plasma glucose (FPG)≥5.6mM or < 6.9mM who had not been diagnosed with any disease and met the inclusion criteria were recruited for this study. The 23 participants were randomly divided into either the HGE (n = 12, 960 mg/d) or placebo (n = 11) group. Outcomes included measurements of efficacy (FPG, postprandial glucose, fasting plasma insulin, postprandial insulin, homeostatic model assessment-insulin resistance, and homeostatic model assessment-β) and safety (adverse events, laboratory tests, electrocardiogram, and vital signs). Results: After 8 wk of HGE supplementation, FPG and postprandial glucose were significantly decreased in the HGE group compared to the placebo group. No clinically significant changes in any safety parameter were observed. Our study revealed that HGE is a potent antidiabetic agent that does not produce noticeable adverse effects. Conclusion: HGE supplementation may be effective for treating impaired fasting glucose individuals.
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KEYWORD
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clinical trial, hydrolyzed ginseng extract, impaired fasting glucose, oral glucose tolerance test, Panax ginseng
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